A General Method for the Enantioselective Synthesis of α‑Chiral Heterocycles

The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er’s are observed...

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Veröffentlicht in:	Organic letters 2012-12, Vol.14 (23), p.6104-6107
Hauptverfasser:	Le, Phong Q, Nguyen, Thien S, May, Jeremy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry, Organic - methods Combinatorial Chemistry Techniques Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Molecular Structure Stereoisomerism
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Beschreibung
Zusammenfassung:	The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er’s are observed for a host of common heteroaryls.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol3030605