Highly Regioselective C–N Bond Formation through C–H Azolation of Indoles Promoted by Iodine in Aqueous Media

Highly Regioselective C–N Bond Formation through C–H Azolation of Indoles Promoted by Iodine in Aqueous Media

An efficient and metal-free method for the direct C–N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.

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Veröffentlicht in:Organic letters 2012-12, Vol.14 (23), p.5832-5835
Hauptverfasser: Wu, Wen-Bin, Huang, Jing-Mei
Format: Artikel
Sprache:eng
Schlagworte:
Azoles - chemical synthesis
Azoles - chemistry
Catalysis
Indoles - chemical synthesis
Indoles - chemistry
Iodine - chemistry
Molecular Structure
Stereoisomerism
Water - chemistry
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Zusammenfassung:An efficient and metal-free method for the direct C–N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302609m