Construction of an All-Carbon Quaternary Stereocenter by the Peptide-Catalyzed Asymmetric Michael Addition of Nitromethane to β-Disubstituted α,β-Unsaturated Aldehydes

Pepping up Michael: An asymmetric Michael addition of nitromethane to β‐disubstituted α,β‐unsaturated aldehydes was realized by a resin‐supported peptide catalyst. Whereas the use of a low‐molecular‐weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity.