Prognostic factors of extremity soft tissue sarcoma in adults. A single institutional analysis

To analyse the prognostic factors for patients treated with limb sparing surgery and radiation for extremity soft tissue sarcoma (E-STS). Medical records of 87 patients with limb sparing surgery and radiation for E-STS were reviewed retrospectively. Disease-free survival (DFS) and disease-specific s...

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Veröffentlicht in:	Cancer radiothérapie 2012-12, Vol.16 (8), p.661-666
Hauptverfasser:	Atean, I., Pointreau, Y., Rosset, P., Garaud, P., De-Pinieux, G., Calais, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Brachytherapy Combined Modality Therapy Curiethérapie Disease-Free Survival Extremities - surgery Extremity soft tissue sarcoma Facteurs pronostiques Female Follow-Up Studies Humans Limb Salvage Male Marge d’exérèse Medical sciences Middle Aged Miscellaneous Neoplasm Metastasis Prognosis Prognostic factors Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Resection margin Retrospective Studies Sarcoma - mortality Sarcoma - radiotherapy Sarcoma - surgery Sarcome des tissus mous des extrémités Soft Tissue Neoplasms - mortality Soft Tissue Neoplasms - radiotherapy Soft Tissue Neoplasms - surgery Tumors Young Adult
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Zusammenfassung:	To analyse the prognostic factors for patients treated with limb sparing surgery and radiation for extremity soft tissue sarcoma (E-STS). Medical records of 87 patients with limb sparing surgery and radiation for E-STS were reviewed retrospectively. Disease-free survival (DFS) and disease-specific survival (DSS) were estimated and factors potentially influencing these outcomes were analysed. With a mean follow-up of 69months, most recurrences occurred within the first 2years. Extent of resection margin was found to improve DFS (P=0.002) and DSS (P=0.002). Brachytherapy combined with external beam radiotherapy (EBRT) improved DFS (P=0.034) and DSS (P=0.019). Tumor size (
ISSN:	1278-3218 1769-6658
DOI:	10.1016/j.canrad.2012.05.021