Inhibition of renin and the (pro)renin receptor system
Abstract Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the...
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| Veröffentlicht in: | Blood pressure 2012-12, Vol.21 (6), p.377-385 |
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| container_title | Blood pressure |
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| creator | Guang, Cuie Jiang, Bo Phillips, Robert D. Milani, Franco |
| description | Abstract
Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the (pro)renin receptor [(P)RR] not only increase the catalytic conversion of angiotensinogen (AGT) to Ang I, but also upregulate the expression of profibrotic genes. This review will discuss the inhibition of renin and the (P)RR system pharmacologically and nutritionally. |
| doi_str_mv | 10.3109/08037051.2012.698042 |
| format | Article |
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Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the (pro)renin receptor [(P)RR] not only increase the catalytic conversion of angiotensinogen (AGT) to Ang I, but also upregulate the expression of profibrotic genes. This review will discuss the inhibition of renin and the (P)RR system pharmacologically and nutritionally.</description><identifier>ISSN: 0803-7051</identifier><identifier>EISSN: 1651-1999</identifier><identifier>DOI: 10.3109/08037051.2012.698042</identifier><identifier>PMID: 22775989</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>(Pro)renin receptor ; aliskiren ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; hand region peptide ; Humans ; profibrotic genes ; prorenin ; renin ; Renin - antagonists & inhibitors ; Renin-Angiotensin System - drug effects ; soyasaponin</subject><ispartof>Blood pressure, 2012-12, Vol.21 (6), p.377-385</ispartof><rights>2012 Scandinavian Foundation for Cardiovascular Research 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-cc44ed1b105f2413dea5246f3c882ee593390f878b9190ac13675711526277d43</citedby><cites>FETCH-LOGICAL-c464t-cc44ed1b105f2413dea5246f3c882ee593390f878b9190ac13675711526277d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22775989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guang, Cuie</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><creatorcontrib>Phillips, Robert D.</creatorcontrib><creatorcontrib>Milani, Franco</creatorcontrib><title>Inhibition of renin and the (pro)renin receptor system</title><title>Blood pressure</title><addtitle>Blood Press</addtitle><description>Abstract
Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the (pro)renin receptor [(P)RR] not only increase the catalytic conversion of angiotensinogen (AGT) to Ang I, but also upregulate the expression of profibrotic genes. This review will discuss the inhibition of renin and the (P)RR system pharmacologically and nutritionally.</description><subject>(Pro)renin receptor</subject><subject>aliskiren</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>hand region peptide</subject><subject>Humans</subject><subject>profibrotic genes</subject><subject>prorenin</subject><subject>renin</subject><subject>Renin - antagonists & inhibitors</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>soyasaponin</subject><issn>0803-7051</issn><issn>1651-1999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A5Ee9dB1Jkk_clFE_ALBi55DNp2yXdpkTbrI_ntbugpePA0Mz7zz8jB2jjAXCOoaShAFZDjngHyeqxIk32MzzDNMUSm1z2Yjko7METuOcQWAQgAcsiPOiyJTpZqx_MUtm0XTN94lvk4CucYlxlVJv6Tkch381bQKZGnd-5DEbeypO2UHtWkjne3mCft4fHi_f05f355e7u9eUytz2afWSkkVLhCymksUFZmMy7wWtiw5UaaEUFCXRblQqMBYFHmRFYgZz4eGlRQn7HLKHZp8bij2umuipbY1jvwmauRcSAESYUDlhNrgYwxU63VoOhO2GkGPxvSPMT0a05Ox4exi92Gz6Kj6PfpRNAC3E9C42ofOfPnQVro329aHOhhnmzjG__vi5k_CkkzbL60JpFd-E9wg8P-O38IUixY</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Guang, Cuie</creator><creator>Jiang, Bo</creator><creator>Phillips, Robert D.</creator><creator>Milani, Franco</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Inhibition of renin and the (pro)renin receptor system</title><author>Guang, Cuie ; Jiang, Bo ; Phillips, Robert D. ; Milani, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-cc44ed1b105f2413dea5246f3c882ee593390f878b9190ac13675711526277d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>(Pro)renin receptor</topic><topic>aliskiren</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>hand region peptide</topic><topic>Humans</topic><topic>profibrotic genes</topic><topic>prorenin</topic><topic>renin</topic><topic>Renin - antagonists & inhibitors</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>soyasaponin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guang, Cuie</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><creatorcontrib>Phillips, Robert D.</creatorcontrib><creatorcontrib>Milani, Franco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood pressure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guang, Cuie</au><au>Jiang, Bo</au><au>Phillips, Robert D.</au><au>Milani, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of renin and the (pro)renin receptor system</atitle><jtitle>Blood pressure</jtitle><addtitle>Blood Press</addtitle><date>2012-12</date><risdate>2012</risdate><volume>21</volume><issue>6</issue><spage>377</spage><epage>385</epage><pages>377-385</pages><issn>0803-7051</issn><eissn>1651-1999</eissn><abstract>Abstract
Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the (pro)renin receptor [(P)RR] not only increase the catalytic conversion of angiotensinogen (AGT) to Ang I, but also upregulate the expression of profibrotic genes. This review will discuss the inhibition of renin and the (P)RR system pharmacologically and nutritionally.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>22775989</pmid><doi>10.3109/08037051.2012.698042</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | (Pro)renin receptor aliskiren Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals hand region peptide Humans profibrotic genes prorenin renin Renin - antagonists & inhibitors Renin-Angiotensin System - drug effects soyasaponin |
| title | Inhibition of renin and the (pro)renin receptor system |
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