Inhibition of renin and the (pro)renin receptor system

Abstract Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the...

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Veröffentlicht in:	Blood pressure 2012-12, Vol.21 (6), p.377-385
Hauptverfasser:	Guang, Cuie, Jiang, Bo, Phillips, Robert D., Milani, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	(Pro)renin receptor aliskiren Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals hand region peptide Humans profibrotic genes prorenin renin Renin - antagonists & inhibitors Renin-Angiotensin System - drug effects soyasaponin
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Zusammenfassung:	Abstract Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT1R) axis. Prorenin and renin bound to the (pro)renin receptor [(P)RR] not only increase the catalytic conversion of angiotensinogen (AGT) to Ang I, but also upregulate the expression of profibrotic genes. This review will discuss the inhibition of renin and the (P)RR system pharmacologically and nutritionally.
ISSN:	0803-7051 1651-1999
DOI:	10.3109/08037051.2012.698042