Kinetics, diagnostic and prognostic value of procalcitonin after cardiac surgery

Cardiac surgery with cardiopulmonary bypass (CPB) can cause a systemic inflammatory response (SIRS) making difficult the interpretation of inflammatory markers. Procalcitonin (PCT) is a marker of inflammation that appears to be a good early marker of infection after cardiac surgery. To study the kin...

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Veröffentlicht in:Annales de biologie clinique (Paris) 2012-10, Vol.70 (5), p.567-580
Hauptverfasser: Kallel, Samy, Abid, Mohamed, Jarraya, Anouar, Abdenadher, Mohamed, Mnif, Emna, Frikha, Imed, Ayadi, Fatma, Karoui, Abdelhamid
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Zusammenfassung:Cardiac surgery with cardiopulmonary bypass (CPB) can cause a systemic inflammatory response (SIRS) making difficult the interpretation of inflammatory markers. Procalcitonin (PCT) is a marker of inflammation that appears to be a good early marker of infection after cardiac surgery. To study the kinetics of PCT after cardiac surgery with CPB and to determine its diagnostic and prognostic value. This is a prospective observational study including 40 adult patients consecutively operated for a coronary or valve surgery with CPB, so programmed or semi-urgent. The anesthetic protocol was standardized for all patients. A determination of PCT and CRP was performed before the CEC, at the decision of the CEC (H0), 4 hours after (H4), then H24, H48, H72 and H96. The rate of PCT and CRP increased significantly from the H4 until 4(th) day compared to baseline. (p
ISSN:1950-6112
DOI:10.1684/abc.2012.0745