Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice
Highlights ► Exposure to radiation decreased the activities of antioxidant enzymes in mice. ► Further radiation increased the levels of TBARS and comet parameters in mice. ► Pre administration with DA restored antioxidant activities in liver of mice. ► DA also decreased the level of TBARS and comet...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.832-840 |
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| container_title | Environmental toxicology and pharmacology |
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| creator | Kalpana, K.B Vishwanathan, P Thayalan, K Menon, Venugopal P |
| description | Highlights ► Exposure to radiation decreased the activities of antioxidant enzymes in mice. ► Further radiation increased the levels of TBARS and comet parameters in mice. ► Pre administration with DA restored antioxidant activities in liver of mice. ► DA also decreased the level of TBARS and comet parameters in mice. ► Histopathological examinations of mice liver confirmed the above findings. |
| doi_str_mv | 10.1016/j.etap.2012.09.002 |
| format | Article |
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| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aminothiazole derivative Animals Comet Assay Dendrodoine analog (DA) Emergency Indoles - chemistry Indoles - pharmacology Liver Liver - metabolism Liver - pathology Liver - radiation effects Male Mice Radiation Radiation-Protective Agents - pharmacology Radioprotector Thiadiazoles - chemistry Thiadiazoles - pharmacology Thiobarbituric Acid Reactive Substances - metabolism X-Rays |
| title | Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice |
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