Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice

Highlights ► Exposure to radiation decreased the activities of antioxidant enzymes in mice. ► Further radiation increased the levels of TBARS and comet parameters in mice. ► Pre administration with DA restored antioxidant activities in liver of mice. ► DA also decreased the level of TBARS and comet...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.832-840
Hauptverfasser:	Kalpana, K.B, Vishwanathan, P, Thayalan, K, Menon, Venugopal P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminothiazole derivative Animals Comet Assay Dendrodoine analog (DA) Emergency Indoles - chemistry Indoles - pharmacology Liver Liver - metabolism Liver - pathology Liver - radiation effects Male Mice Radiation Radiation-Protective Agents - pharmacology Radioprotector Thiadiazoles - chemistry Thiadiazoles - pharmacology Thiobarbituric Acid Reactive Substances - metabolism X-Rays
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Beschreibung
Zusammenfassung:	Highlights ► Exposure to radiation decreased the activities of antioxidant enzymes in mice. ► Further radiation increased the levels of TBARS and comet parameters in mice. ► Pre administration with DA restored antioxidant activities in liver of mice. ► DA also decreased the level of TBARS and comet parameters in mice. ► Histopathological examinations of mice liver confirmed the above findings.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2012.09.002