Activation of the Ahr signalling pathway by polychlorobiphenyls causes a marked induction of cytochrome P450 only after depletion of vitellogenin in Sparus aurata

Highlights ► PCBs active Ahr causing a marked induction of CYP1A1 only after depletion of Vtg. ► The data show the systemic exploration of the ubiquitin system as a target of environmental. ► PCBs modulate the activity of receptors and display cross-talk between the pathways involved.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.735-742
Hauptverfasser:	Calò, Margherita, Casella, Stefania, Panzera, Michele, Cascio, Patrizia Lo, Alberghina, Daniela, Piccione, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl hydrocarbon receptor Biomarkers - metabolism Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 Emergency Endocrine Disruptors - toxicity Enzyme Induction - drug effects Estrogen receptor Fish Liver - drug effects Liver - metabolism Liver - pathology Polychlorinated Biphenyls - toxicity Polychlorobiphenyls Receptors, Aryl Hydrocarbon - metabolism Sea Bream Vitellogenin Vitellogenins - metabolism Water Pollutants, Chemical - toxicity
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Beschreibung
Zusammenfassung:	Highlights ► PCBs active Ahr causing a marked induction of CYP1A1 only after depletion of Vtg. ► The data show the systemic exploration of the ubiquitin system as a target of environmental. ► PCBs modulate the activity of receptors and display cross-talk between the pathways involved.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2012.09.014