Recent progress in studies of metallic nickel and nickel-based nanoparticles’ genotoxicity and carcinogenicity

Highlights ► Metallic Ni NPs: few studies utilizing genotoxicity endpoints such as DNA damage or micronucleus formation. No in vivo studies for metallic Ni NPs so far. ► Metallic Ni NPs causes sarcoma and activates or up regulates genes in pathways related to cancer. ► Ni based NPs activate genes su...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.644-650
Hauptverfasser:	Magaye, Ruth, Zhao, Jinshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenicity Carcinogens - toxicity DNA Damage Emergency Environmental Exposure - statistics & numerical data Genotoxicity Metal Nanoparticles - toxicity Mutagens - toxicity Nanoparticles Nickel Nickel - toxicity Particle Size Risk Assessment Toxicity Tests
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Beschreibung
Zusammenfassung:	Highlights ► Metallic Ni NPs: few studies utilizing genotoxicity endpoints such as DNA damage or micronucleus formation. No in vivo studies for metallic Ni NPs so far. ► Metallic Ni NPs causes sarcoma and activates or up regulates genes in pathways related to cancer. ► Ni based NPs activate genes such as HO-1 and HIF-1α. ► Inflammation a key factor in both genotoxicity and carcinogenicity of Ni based NPs. ► A lack of epidemiological studies for both metallic Ni and Ni based nanoparticles.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2012.08.012