Ameliorative effect of silibinin against N -nitrosodimethylamine-induced hepatic fibrosis in rats
Highlights ► DMN induced fibrosis is stable after termination of its intoxication. ► SBN possesses the antioxidant, free radical quenching, and membrane stabilizing properties. ► Silibinin ameliorates DMN induced hepatic fibrosis.
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.1004-1013 |
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| container_end_page | 1013 |
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| container_issue | 3 |
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| container_title | Environmental toxicology and pharmacology |
| container_volume | 34 |
| creator | Ezhilarasan, Devaraj Karthikeyan, Sivanesan Vivekanandan, Palani |
| description | Highlights ► DMN induced fibrosis is stable after termination of its intoxication. ► SBN possesses the antioxidant, free radical quenching, and membrane stabilizing properties. ► Silibinin ameliorates DMN induced hepatic fibrosis. |
| doi_str_mv | 10.1016/j.etap.2012.07.004 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2012-11, Vol.34 (3), p.1004-1013 |
| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Alanine Transaminase - metabolism Animals Antioxidants - pharmacology Aspartate Aminotransferases - metabolism Dimethylnitrosamine - toxicity Emergency Female Hepatic fibrosis Hepatic stellate cells Liver - drug effects Liver - metabolism Liver - pathology Male N-Nitrosodimethylamine Oxidative Stress Rats Rats, Wistar Silibinin Silymarin - pharmacology |
| title | Ameliorative effect of silibinin against N -nitrosodimethylamine-induced hepatic fibrosis in rats |
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