Ameliorative effect of silibinin against N -nitrosodimethylamine-induced hepatic fibrosis in rats

Ameliorative effect of silibinin against N -nitrosodimethylamine-induced hepatic fibrosis in rats

Highlights ► DMN induced fibrosis is stable after termination of its intoxication. ► SBN possesses the antioxidant, free radical quenching, and membrane stabilizing properties. ► Silibinin ameliorates DMN induced hepatic fibrosis.

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Veröffentlicht in:Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.1004-1013
Hauptverfasser: Ezhilarasan, Devaraj, Karthikeyan, Sivanesan, Vivekanandan, Palani
Format: Artikel
Sprache:eng
Schlagworte:
Alanine Transaminase - metabolism
Animals
Antioxidants - pharmacology
Aspartate Aminotransferases - metabolism
Dimethylnitrosamine - toxicity
Emergency
Female
Hepatic fibrosis
Hepatic stellate cells
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
N-Nitrosodimethylamine
Oxidative Stress
Rats
Rats, Wistar
Silibinin
Silymarin - pharmacology
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Zusammenfassung:Highlights ► DMN induced fibrosis is stable after termination of its intoxication. ► SBN possesses the antioxidant, free radical quenching, and membrane stabilizing properties. ► Silibinin ameliorates DMN induced hepatic fibrosis.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.07.004