Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls

Abstract To identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral...

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Veröffentlicht in:	Psychiatry research 2012-12, Vol.200 (2), p.1018-1021
Hauptverfasser:	Maschietto, Mariana, Silva, Aderbal R, Puga, Renato D, Lima, Leandro, Pereira, Carlos B, Nakano, Eduardo Y, Mello, Barbara, Gama, Clarissa S, Belmonte-de-Abreu, Paulo, Carraro, Dirce M, Palha, Joana A, Brentani, Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Biological and medical sciences Biomarkers - blood Diagnosis, Differential Drugs Female Gene Expression Gene Expression Profiling Humans Lymphocytes - metabolism Male Medical sciences Peripheral Molecular Marker Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - metabolism Sensitivity and Specificity
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Zusammenfassung:	Abstract To identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2012.04.030