Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations

Mutual clinical and molecular interactions between iron and glucose metabolism have been reported. We aimed to investigate a potential effect of glucose on iron homeostasis. We found that serum iron concentrations gradually decreased over 180 min after the administration of 75 g of glucose from 109....

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Veröffentlicht in:	The Journal of nutritional biochemistry 2013, Vol.24 (1), p.112-117
Hauptverfasser:	Aigner, Elmar, Felder, Thomas K, Oberkofler, Hannes, Hahne, Penelope, Auer, Simon, Soyal, Selma, Stadlmayr, Andreas, Schwenoha, Karin, Pirich, Christian, Hengster, Paul, Datz, Christian, Patsch, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism cell culture Cells, Cultured Female glucose Glucose - metabolism Glucose - pharmacology Glucose Tolerance Test Hepatocytes - drug effects Hepatocytes - metabolism hepcidin Hepcidins homeostasis Homeostasis - drug effects Humans ingestion insulin Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulinoma - drug therapy Insulinoma - metabolism iron Iron - blood islets of Langerhans Male metabolism Middle Aged Rats secretion tap water
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Zusammenfassung:	Mutual clinical and molecular interactions between iron and glucose metabolism have been reported. We aimed to investigate a potential effect of glucose on iron homeostasis. We found that serum iron concentrations gradually decreased over 180 min after the administration of 75 g of glucose from 109.8±45.4 mg/L to 94.4±40.4 mg/L (P
ISSN:	0955-2863 1873-4847
DOI:	10.1016/j.jnutbio.2012.02.017