Roles of heterotypic CCN2/CTGF–CCN3/NOV and homotypic CCN2–CCN2 interactions in expression of the differentiated phenotype of chondrocytes

To identify proteins that regulate CCN2 activity, we carried out GAL4‐based yeast two‐hybrid screening with a cDNA library derived from a chondrocytic cell line, HCS‐2/8. CCN2/CTGF and CCN3/NOV polypeptides were picked up as CCN2‐binding proteins, and CCN2–CCN2 and CCN2–CCN3 binding domains were ide...

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Veröffentlicht in:The FEBS journal 2012-10, Vol.279 (19), p.3584-3597
Hauptverfasser: Hoshijima, Mitsuhiro, Hattori, Takako, Aoyama, Eriko, Nishida, Takashi, Yamashiro, Takashi, Takigawa, Masaharu
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Sprache:eng
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