New group of class III antiarrhythmic drugs: piperid-4-ylethane derivatives

New group of class III antiarrhythmic drugs: piperid-4-ylethane derivatives

A series of new piperid-4-ylethane derivatives possessing antiarrhythmic activity has been synthesized and studied. The most active compound, 1-(4-fluorophenyl)-1-(4-nitrobenzoylamino)-2-( N -ethylpiperid-4-yl)ethane (niferidyl) hydrochloride, was selected for clinical trials as a potential class II...

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Veröffentlicht in:Pharmaceutical chemistry journal 2011-05, Vol.45 (2), p.65-74
Hauptverfasser: Glushkov, R. G., Yuzhakov, S. D., L’vov, A. I., Zhikhareva, G. P., Davydova, N. K., Sizova, O. S., Asnina, V. V., Salin, E. N.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-arrhythmia drugs
Arrhythmia
Clinical trials
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:A series of new piperid-4-ylethane derivatives possessing antiarrhythmic activity has been synthesized and studied. The most active compound, 1-(4-fluorophenyl)-1-(4-nitrobenzoylamino)-2-( N -ethylpiperid-4-yl)ethane (niferidyl) hydrochloride, was selected for clinical trials as a potential class III antiarrhythmic drug.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0562-6