A new group of 1-and 7-[ω-(benzhydryl-1-alkyl]-3methylxanthine derivatives with antihistamine activity

Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1-and 7-[ω-(benzhydryl-1)alkyl]-3-methylxanthine derivatives which functioned as histamine receptor blockers. The compound which was most active, had the longest duration of action, and the lowest tox...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2011-04, Vol.45 (1), p.1-11, Article 1
Hauptverfasser:	Glushkov, R. G., Yuzhakov, S. D., Alekseev, M. V., Fominova, O. S., Shorr, V. A., Zhdanov, G. F., Dolginova, E. M., Sazonova, N. M., Andreeva, N. I., Salin, E. N., Asnina, V. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihistamines Clinical trials Histamine receptors Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy The Search for New Therapeutic Agents Toxicity
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