A new group of 1-and 7-[ω-(benzhydryl-1-alkyl]-3methylxanthine derivatives with antihistamine activity

A new group of 1-and 7-[ω-(benzhydryl-1-alkyl]-3methylxanthine derivatives with antihistamine activity

Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1-and 7-[ω-(benzhydryl-1)alkyl]-3-methylxanthine derivatives which functioned as histamine receptor blockers. The compound which was most active, had the longest duration of action, and the lowest tox...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2011-04, Vol.45 (1), p.1-11, Article 1
Hauptverfasser: Glushkov, R. G., Yuzhakov, S. D., Alekseev, M. V., Fominova, O. S., Shorr, V. A., Zhdanov, G. F., Dolginova, E. M., Sazonova, N. M., Andreeva, N. I., Salin, E. N., Asnina, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Antihistamines
Clinical trials
Histamine receptors
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
The Search for New Therapeutic Agents
Toxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1-and 7-[ω-(benzhydryl-1)alkyl]-3-methylxanthine derivatives which functioned as histamine receptor blockers. The compound which was most active, had the longest duration of action, and the lowest toxicity was 7-[4-(4-benzhydrylpiperazinyl-1)butyl]-3-methylxanthine succinate, and this compound was selected for clinical trials.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0549-3