Synthesis and antioxidant activity of new 1,2,4-triazole derivatives

A series of new derivatives of 1,2,4-triazoles have been synthesized and their antioxidant properties have been studied. It was established that the obtained compounds exhibit a stabilizing effect on cell membranes and demonstrate antioxidant activity with respect to erythrocytes under oxidative str...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2011, Vol.44 (10), p.525-527
Hauptverfasser:	Kochikyan, T. V, Samvelyan, M. A, Arutyunyan, E. V, Arutyunyan, V. S, Avetisyan, A. A, Malakyan, M. G, Vardevanyan, L. A, Badzhinyan, S. A
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,4-triazole derivatives antioxidant activity Antioxidants Cell membranes Chemical properties Erythrocytes Medicine membrane stabilizing effect Organic Chemistry Oxidative stress Pharmacology/Toxicology Pharmacy Search for New Drugs Triazoles
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Beschreibung
Zusammenfassung:	A series of new derivatives of 1,2,4-triazoles have been synthesized and their antioxidant properties have been studied. It was established that the obtained compounds exhibit a stabilizing effect on cell membranes and demonstrate antioxidant activity with respect to erythrocytes under oxidative stress conditions.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-011-0509-y