Synthesis and antiserotoninergic activity of new tropane derivatives

Tropane derivatives have been synthesized with the aim of finding serotonin antagonists with potential antimigraine activity. Aromatic and heteroaromatic esters of tropan-3-oxime were obtained. Their cerebrovascular activity as manifested by antiserotonin properties has been studied. On this basis t...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2010-12, Vol.44 (9), p.472-475
Hauptverfasser:	Kostochka, L. M, Gan'shina, T. S, Mirzoyan, R. S, Seredenin, S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids anitmigraine activity Antagonists Aromatics Drugs Esters Medicine Migraine Organic Chemistry Pharmacology/Toxicology Pharmacy Serotonin tropane tropoxin
Online-Zugang:	Volltext
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