Synthesis and antiserotoninergic activity of new tropane derivatives

Synthesis and antiserotoninergic activity of new tropane derivatives

Tropane derivatives have been synthesized with the aim of finding serotonin antagonists with potential antimigraine activity. Aromatic and heteroaromatic esters of tropan-3-oxime were obtained. Their cerebrovascular activity as manifested by antiserotonin properties has been studied. On this basis t...

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Veröffentlicht in:Pharmaceutical chemistry journal 2010-12, Vol.44 (9), p.472-475
Hauptverfasser: Kostochka, L. M, Gan'shina, T. S, Mirzoyan, R. S, Seredenin, S. B
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
anitmigraine activity
Antagonists
Aromatics
Drugs
Esters
Medicine
Migraine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Serotonin
tropane
tropoxin
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Zusammenfassung:Tropane derivatives have been synthesized with the aim of finding serotonin antagonists with potential antimigraine activity. Aromatic and heteroaromatic esters of tropan-3-oxime were obtained. Their cerebrovascular activity as manifested by antiserotonin properties has been studied. On this basis the new antimigraine drug tropoxin has been discovered.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0494-6