Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines

Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3‐substituted morpholines and the diastereoselective synthesis of 2,5‐substituted piperazines.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-12, Vol.51 (49), p.12219-12223
Hauptverfasser: Zhai, Huimin, Borzenko, Andrey, Lau, Ying Yin, Ahn, Shin Hye, Schafer, Laurel L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3‐substituted morpholines and the diastereoselective synthesis of 2,5‐substituted piperazines.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206826