Intercellular K+ accumulation depolarizes Type I vestibular hair cells and their associated afferent nerve calyx

Graphical abstract Highlights ► K+ can accumulate in the synaptic cleft around Type I hair cells. ► K+ accumulation depolarizes both the pre- and postsynaptic membranes. ► The depolarization produced by K+ accumulation participates in afferent vestibular signaling.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-12, Vol.227, p.232-246
Hauptverfasser:	Contini, D, Zampini, V, Tavazzani, E, Magistretti, J, Russo, G, Prigioni, I, Masetto, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Afferent Pathways - physiology Animals Biological and medical sciences Biophysical Phenomena - physiology Biophysics Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Electric Stimulation Fundamental and applied biological sciences. Psychology hair cell Hair Cells, Vestibular - classification Hair Cells, Vestibular - metabolism In Vitro Techniques Intracellular Fluid - metabolism Mice Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration nerve afferent calyx Nerve Net - physiology Neurology Patch-Clamp Techniques Potassium - metabolism semicircular canal Vertebrates: nervous system and sense organs vestibular Vestibule, Labyrinth - cytology
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► K+ can accumulate in the synaptic cleft around Type I hair cells. ► K+ accumulation depolarizes both the pre- and postsynaptic membranes. ► The depolarization produced by K+ accumulation participates in afferent vestibular signaling.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.051