Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation

Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation

We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolu...

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Veröffentlicht in:Physical review. E, Statistical, nonlinear, and soft matter physics Statistical, nonlinear, and soft matter physics, 2012-08, Vol.86 (2 Pt 1), p.021925-021925, Article 021925
Hauptverfasser: Lin, Chien Y, Huang, Jung Y, Lo, Leu-Wei
Format: Artikel
Sprache:eng
Schlagworte:
Lasers
Luminescent Proteins - chemistry
Models, Molecular
Photons
Protein Conformation
Stochastic Processes
Thermodynamics
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Zusammenfassung:We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed to slow conformational fluctuations of the protein matrix.
ISSN:1539-3755
1550-2376
DOI:10.1103/PhysRevE.86.021925