Acute Otitis Media Replacement and Recurrence in the Finnish Otitis Media Vaccine Trial

We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impa...

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Veröffentlicht in:	Clinical infectious diseases 2012-12, Vol.55 (12), p.1673-1676
Hauptverfasser:	Jokinen, Jukka, Palmu, Arto A., Kilpi, Terhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Bacterial diseases Biological and medical sciences BRIEF REPORT Child, Preschool Children Clinical trials Conjugate vaccines Control groups Ear diseases Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ent and stomatologic bacterial diseases Finland - epidemiology Heptavalent Pneumococcal Conjugate Vaccine Human bacterial diseases Humans Infant Infectious diseases Medical sciences Middle ear ventilation Non tumoral diseases Otitis media Otitis Media - epidemiology Otitis Media - microbiology Otitis Media - prevention & control Otolaryngology Otorhinolaryngology. Stomatology Pathogens Pneumococcal Vaccines - administration & dosage Recurrence Relapse Respiratory diseases School age children Vaccination Vaccines
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Beschreibung
Zusammenfassung:	We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cis799