Calculating an individual maxPTH to aid diagnosis of normocalemic primary hyperparathyroidism

Background We aimed to validate a nomogram for diagnosing primary hyperparathyroidism (PHP), particularly when normocalcemic PHP and vitamin D (VitD25) deficiency coexist. Methods The nomogram calculates maximal upper limit of normal PTH unique for each person by maxPTH = 120 − [6*calcium] − [½*VitD...

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Veröffentlicht in:	Surgery 2012-12, Vol.152 (6), p.1184-1192
Hauptverfasser:	Jin, Judy, MD, Mitchell, Jamie, MD, Shin, Joyce, MD, Berber, Eren, MD, Siperstein, Allan E., MD, Milas, Mira, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Calcium - blood Child Endocrinopathies General aspects Humans Hyperparathyroidism, Primary - blood Hyperparathyroidism, Primary - complications Hyperparathyroidism, Primary - diagnosis Medical sciences Middle Aged Nomograms Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroid Hormone - blood Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Surgery Vitamin D - blood Vitamin D Deficiency - complications Young Adult
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Zusammenfassung:	Background We aimed to validate a nomogram for diagnosing primary hyperparathyroidism (PHP), particularly when normocalcemic PHP and vitamin D (VitD25) deficiency coexist. Methods The nomogram calculates maximal upper limit of normal PTH unique for each person by maxPTH = 120 − [6calcium] − [½VitD25] + [¼*age]. PHP is suspected when serum PTH exceeds maxPTH. Normocalcemic PHP (NCPHP) was defined as always normal serum calcium (8.5–10.5 mg/dL) with PTH >60 pg/mL preoperatively and VitD25 deficiency as
ISSN:	0039-6060 1532-7361
DOI:	10.1016/j.surg.2012.08.013