Separation and study of the range of plasminogen isoforms in patients with prostate cancer

Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the develop...

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Veröffentlicht in:	Biochemistry (Moscow) 2012-09, Vol.77 (9), p.1065-1071
Hauptverfasser:	Shin, E. F., Vodolazhsky, D. I., Golikov, A. Yu, Belova, T. N., Boyko, N. V., Zimakov, D. V., Cherkasova, E. N., Kogan, M. I., Chibichian, M. B., Moshkovskii, S. A., Tarasov, V. A., Matishov, D. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Cancer patients Care and treatment Developmental stages Glycoproteins Humans Life Sciences Male Mass spectrometry Microbiology Middle Aged Oncology, Experimental Plasma Plasminogen - analysis Plasminogen - isolation & purification Prostate cancer Prostatic Neoplasms - blood Proteases Protein Isoforms - blood Proteins Thrombolytic drugs
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Beschreibung
Zusammenfassung:	Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher p I values compared to isoforms found in the control group.
ISSN:	0006-2979 1608-3040
DOI:	10.1134/S0006297912090143