Comparative studies in vivo of free and liposomal forms of photosensitizer on a base of hydrophilic derivative of chlorin e sub(6)

Comparative studies in vivo of free and liposomal forms of photosensitizer on a base of hydrophilic derivative of chlorin e sub(6)

This work presents the results of a comparative study in vivo of photosensitizer based on hydrophilic derivative of chlorin e6 upon systemic administration in commercially available aqueous solution and liposomal form. It is demonstrated that newly developed liposomal form provides more selective ac...

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Veröffentlicht in:Journal of drug delivery science and technology 2012-08, Vol.22 (4), p.291-294
Hauptverfasser: Yen, TTH, Meerovich, I G, Meerovich, G A, Pozdeev, VI, Karshieva, S S, Orlova, O L, Polozkova, A P, Oborotova, NA
Format: Artikel
Sprache:eng
Schlagworte:
Drug delivery
Shelf life
Tumors
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Zusammenfassung:This work presents the results of a comparative study in vivo of photosensitizer based on hydrophilic derivative of chlorin e6 upon systemic administration in commercially available aqueous solution and liposomal form. It is demonstrated that newly developed liposomal form provides more selective accumulation of photosensitizer in tumor tissue and efficiency of antitumor action, as well as achieving an enhanced storage stability in comparison to the original form.
ISSN:1773-2247