Effect of breast cancer adjuvant therapies on potential biomarkers of pulmonary inflammation

The aim of this study was to investigate the effect of breast cancer adjuvant therapies on the levels of circulating surfactant protein-D (SP-D), C-Reactive protein (CRP) and soluble receptor for advanced glycation end-products (sRAGE), as potential biomarkers of subclinical pulmonary inflammation....

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Veröffentlicht in:	Anticancer research 2012-11, Vol.32 (11), p.4993-5002
Hauptverfasser:	Piperis, Maria, Provatopoulou, Xeni, Sagkriotis, Alexandros, Kalogera, Eleni, Ampatzoglou, Emmanouil, Zografos, George C, Athanasiou, Eleni, Gounaris, Antonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic Agents - therapeutic use Biomarkers - blood Breast Neoplasms - therapy C-Reactive Protein - analysis Chemoradiotherapy - adverse effects Chemotherapy, Adjuvant - adverse effects Enzyme-Linked Immunosorbent Assay Female Humans Middle Aged Pneumonia - blood Pneumonia - etiology Pulmonary Surfactant-Associated Protein D - blood Radiotherapy, Adjuvant - adverse effects Receptor for Advanced Glycation End Products Receptors, Immunologic - blood Trastuzumab
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Zusammenfassung:	The aim of this study was to investigate the effect of breast cancer adjuvant therapies on the levels of circulating surfactant protein-D (SP-D), C-Reactive protein (CRP) and soluble receptor for advanced glycation end-products (sRAGE), as potential biomarkers of subclinical pulmonary inflammation. The soluble molecules were serially determined in 38 patients, prior to the initiation of radiation therapy (RT) and during adjuvant treatment, using immunoassays. Significantly higher levels of all three biomarkers were observed in patients prior to the initiation of RT compared to healthy controls (CRP: p
ISSN:	1791-7530