Visfatin and its role in obesity development

Abstract Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamid...

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Veröffentlicht in:	Diabetes & metabolic syndrome clinical research & reviews 2012-04, Vol.6 (2), p.120-124
Hauptverfasser:	Stastny, Jiri, Bienertova-Vasku, Julie, Vasku, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytokines Adipose Tissue - metabolism Cytokines - metabolism Endocrinology & Metabolism Female Humans Inflammation - metabolism Insulin Resistance Insulin-Secreting Cells - metabolism Lipid metabolism Lipids - blood Male NAMPT Nicotinamide Phosphoribosyltransferase - metabolism Nicotinamide Phosphoribosyltransferase - pharmacology Obesity Obesity - metabolism Visfatin
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Zusammenfassung:	Abstract Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.
ISSN:	1871-4021 1878-0334
DOI:	10.1016/j.dsx.2012.08.011