Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-α-Amino Acid Derivatives

Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-α-Amino Acid Derivatives

A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)2 (5 mol %) to give the cyclic dehydro-α-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.

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Veröffentlicht in:Organic letters 2012-11, Vol.14 (22), p.5640-5643
Hauptverfasser: Luo, Yueting, Lu, Xiaoxia, Ye, Yong, Guo, Ya, Jiang, Huanfeng, Zeng, Wei
Format: Artikel
Sprache:eng
Schlagworte:
Amines - chemistry
Amino Acids, Cyclic - chemical synthesis
Amino Acids, Cyclic - chemistry
Catalysis
Cyclization
Glyoxylates - chemical synthesis
Glyoxylates - chemistry
Molecular Structure
Palladium - chemistry
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Zusammenfassung:A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)2 (5 mol %) to give the cyclic dehydro-α-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302483f