Structural and functional characterization of neuropeptide Y in a primitive teleost, the Japanese eel ( Anguilla japonica )

Highlights ► The full-length cDNA encoding for Neuropeptide Y (NPY) was first cloned from the brain of Japanese eel ( Anguilla japonica ). ► Four days of food deprivation induced significant increase of NPY mRNA expression in the hypothalamus and optic tectum thalamus. ► The biological effects of Ja...

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Veröffentlicht in:	General and comparative endocrinology 2012-10, Vol.179 (1), p.99-106
Hauptverfasser:	Li, Shuisheng, Zhao, Liping, Xiao, Ling, Liu, Qiongyu, Zhou, Wenyi, Qi, Xin, Chen, Huapu, Yang, Huirong, Liu, Xiaochun, Zhang, Yong, Lin, Haoran
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acids Anguilla - genetics Anguilla - metabolism Anguilla japonica Animals Biological activity Cloning, Molecular complementary DNA DNA, Complementary - chemistry Endocrinology & Metabolism energy balance Expression pattern Fish Proteins - chemistry Fish Proteins - genetics Fish Proteins - physiology follicle-stimulating hormone Food Deprivation Gene Expression Gene Expression Regulation genes gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - metabolism hypothalamus Hypothalamus - metabolism in vitro studies intraperitoneal injection Japanese eel luteinizing hormone mammals Marine messenger RNA Molecular Sequence Data Neuropeptide Y Neuropeptide Y - chemistry Neuropeptide Y - genetics Neuropeptide Y - physiology Open Reading Frames Pituitary Hormones - metabolism quantitative polymerase chain reaction RNA, Messenger - metabolism Sequence Alignment sequence analysis somatotropin Superior Colliculi - metabolism Teleostei thalamus thyrotropin
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Zusammenfassung:	Highlights ► The full-length cDNA encoding for Neuropeptide Y (NPY) was first cloned from the brain of Japanese eel ( Anguilla japonica ). ► Four days of food deprivation induced significant increase of NPY mRNA expression in the hypothalamus and optic tectum thalamus. ► The biological effects of Japanese eel NPY on the synthesis of hypothalamic mGnRH and pituitary hormone were investigated. ► Our studies demonstrated that NPY involved in the regulation of energy homeostasis, reproduction and HPT axis in the eel species.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2012.07.018