Fetuin-A Function in Systemic Mineral Metabolism

Fetuin-A Function in Systemic Mineral Metabolism

Fetuin-A is a liver-derived plasma protein involved in calcified matrix metabolism. Fetuin-A mediates the formation and stabilization of calciprotein particles (CPPs), soluble colloids made of fetuin-A, further serum proteins, and calcium phosphate mineral. CPP formation ensures mineral solubilizati...

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Veröffentlicht in:Trends in cardiovascular medicine 2012-11, Vol.22 (8), p.197-201
Hauptverfasser: Herrmann, Marietta, Kinkeldey, Anne, Jahnen-Dechent, Willi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Atherosclerosis
Blood Proteins - metabolism
Calcinosis - metabolism
Calcium Phosphates - metabolism
Cardiovascular
Cardiovascular disease
Cell culture
Fetuins - metabolism
Homeostasis
Humans
Lipids
Metabolic disorders
Metabolism
Minerals - metabolism
Mononuclear Phagocyte System - metabolism
Mortality
Osteopontin - metabolism
Phosphorylation
Protein Binding
Proteins
Smooth muscle
Studies
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Beschreibung
Zusammenfassung:Fetuin-A is a liver-derived plasma protein involved in calcified matrix metabolism. Fetuin-A mediates the formation and stabilization of calciprotein particles (CPPs), soluble colloids made of fetuin-A, further serum proteins, and calcium phosphate mineral. CPP formation ensures mineral solubilization and rapid clearance from circulation by macrophages of the mononuclear phagocyte system, thus preventing pathological calcification. Accordingly, low levels of free serum fetuin-A and high serum CPPs are associated with pathological calcification in patients suffering from chronic kidney disease.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2012.07.020