Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice

The root decoction of Cnestis ferruginea (CF) Vahl DC (Connaraceae) is used in traditional African medicine in the management of psychiatric disorders. This study presents the antidepressant and anxiolytic effects of amentoflavone (CF-2) isolated from the root extract of C. ferruginea. The antidepre...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2012-12, Vol.103 (2), p.322-331
Hauptverfasser:	Ishola, Ismail O., Chatterjee, Manavi, Tota, Santoshkumar, Tadigopulla, Narender, Adeyemi, Olufunmilayo O., Palit, Gautam, Shukla, Rakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amentoflavone Animals Anti-Anxiety Agents - isolation & purification Anti-Anxiety Agents - pharmacology Antidepressive Agents - isolation & purification Antidepressive Agents - pharmacology Anxiety Biflavonoids - isolation & purification Biflavonoids - pharmacology Connaraceae - chemistry Depression Elevated plus maze Flumazenil Forced swimming test Male Maze Learning Metergoline Mice Motor Activity - drug effects Plant Extracts - isolation & purification Plant Extracts - pharmacology Rotarod Performance Test
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Zusammenfassung:	The root decoction of Cnestis ferruginea (CF) Vahl DC (Connaraceae) is used in traditional African medicine in the management of psychiatric disorders. This study presents the antidepressant and anxiolytic effects of amentoflavone (CF-2) isolated from the root extract of C. ferruginea. The antidepressant effect was studied using the forced swimming (FST) and tail suspension tests (TST) while the hole-board, elevated plus maze (EPM) and light/dark tests were used to evaluate the anxiolytic effect. Acute treatment with CF extract and amentoflavone significantly (p
ISSN:	0091-3057 1873-5177
DOI:	10.1016/j.pbb.2012.08.017