Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET
Purpose The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue. Methods Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventr...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2012-12, Vol.39 (12), p.1920-1926 |
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| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 39 |
| creator | Fuchs, Tobias A. Ghadri, Jelena R. Stehli, Julia Gebhard, Catherine Kazakauskaite, Egle Klaeser, Bernd Gaemperli, Oliver Fiechter, Michael Kaufmann, Philipp A. |
| description | Purpose
The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
Methods
Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to
18
F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar ( |
| doi_str_mv | 10.1007/s00259-012-2212-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1151035816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1151035816</sourcerecordid><originalsourceid>FETCH-LOGICAL-c302y-5cb01dbce5926ec904b3510c8e3f3c27b408b123840d6a74c4a22ba2413e9e3f3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0E4lH4ADbISzaBGefNDpW2IFWCRVlbjjMpRolT7KZS_h5XBZZsbEtz7tX4MHaNcIcA-b0HEGkZAYpIiHCMR-wcMyyjHIry-O-dwxm78P4TAAtRlKfsTIhSZDnCOZPP46avyXrijtamt54bywdL9kNZTTWfrrgJ861pRm57uzOqaol3Y6-Vq83QPfCdak2ttiHLd-T84DkW82j-tOBvs9UlO2lU6-nq556w9_lsNX2Olq-Ll-njMtIxiDFKdQVYV5rSsBjpEpIqThF0QXETa5FXCRQVirhIoM5UnuhECVEpkWBM5Z6ZsNtD78b1XwP5reyM19S2ylI_eIkY6uK0wCygeEC167131MiNM51yo0SQe6_y4FUGr3LvVY4hc_NTP1Qd1X-JX5EBEAfAh5Fdk5Of_eBs-PI_rd8NDYL6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1151035816</pqid></control><display><type>article</type><title>Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Fuchs, Tobias A. ; Ghadri, Jelena R. ; Stehli, Julia ; Gebhard, Catherine ; Kazakauskaite, Egle ; Klaeser, Bernd ; Gaemperli, Oliver ; Fiechter, Michael ; Kaufmann, Philipp A.</creator><creatorcontrib>Fuchs, Tobias A. ; Ghadri, Jelena R. ; Stehli, Julia ; Gebhard, Catherine ; Kazakauskaite, Egle ; Klaeser, Bernd ; Gaemperli, Oliver ; Fiechter, Michael ; Kaufmann, Philipp A.</creatorcontrib><description>Purpose
The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
Methods
Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to
18
F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
Results
Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
Conclusion
Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-012-2212-y</identifier><identifier>PMID: 22926710</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Cardiology ; Cicatrix - diagnostic imaging ; Coronary Artery Disease - diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Heart - diagnostic imaging ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardium - pathology ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Positron-Emission Tomography ; Radiology ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2012-12, Vol.39 (12), p.1920-1926</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302y-5cb01dbce5926ec904b3510c8e3f3c27b408b123840d6a74c4a22ba2413e9e3f3</citedby><cites>FETCH-LOGICAL-c302y-5cb01dbce5926ec904b3510c8e3f3c27b408b123840d6a74c4a22ba2413e9e3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-012-2212-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-012-2212-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22926710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuchs, Tobias A.</creatorcontrib><creatorcontrib>Ghadri, Jelena R.</creatorcontrib><creatorcontrib>Stehli, Julia</creatorcontrib><creatorcontrib>Gebhard, Catherine</creatorcontrib><creatorcontrib>Kazakauskaite, Egle</creatorcontrib><creatorcontrib>Klaeser, Bernd</creatorcontrib><creatorcontrib>Gaemperli, Oliver</creatorcontrib><creatorcontrib>Fiechter, Michael</creatorcontrib><creatorcontrib>Kaufmann, Philipp A.</creatorcontrib><title>Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
Methods
Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to
18
F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
Results
Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
Conclusion
Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.</description><subject>Aged</subject><subject>Cardiology</subject><subject>Cicatrix - diagnostic imaging</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardium - pathology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Positron-Emission Tomography</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0E4lH4ADbISzaBGefNDpW2IFWCRVlbjjMpRolT7KZS_h5XBZZsbEtz7tX4MHaNcIcA-b0HEGkZAYpIiHCMR-wcMyyjHIry-O-dwxm78P4TAAtRlKfsTIhSZDnCOZPP46avyXrijtamt54bywdL9kNZTTWfrrgJ861pRm57uzOqaol3Y6-Vq83QPfCdak2ttiHLd-T84DkW82j-tOBvs9UlO2lU6-nq556w9_lsNX2Olq-Ll-njMtIxiDFKdQVYV5rSsBjpEpIqThF0QXETa5FXCRQVirhIoM5UnuhECVEpkWBM5Z6ZsNtD78b1XwP5reyM19S2ylI_eIkY6uK0wCygeEC167131MiNM51yo0SQe6_y4FUGr3LvVY4hc_NTP1Qd1X-JX5EBEAfAh5Fdk5Of_eBs-PI_rd8NDYL6</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Fuchs, Tobias A.</creator><creator>Ghadri, Jelena R.</creator><creator>Stehli, Julia</creator><creator>Gebhard, Catherine</creator><creator>Kazakauskaite, Egle</creator><creator>Klaeser, Bernd</creator><creator>Gaemperli, Oliver</creator><creator>Fiechter, Michael</creator><creator>Kaufmann, Philipp A.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET</title><author>Fuchs, Tobias A. ; Ghadri, Jelena R. ; Stehli, Julia ; Gebhard, Catherine ; Kazakauskaite, Egle ; Klaeser, Bernd ; Gaemperli, Oliver ; Fiechter, Michael ; Kaufmann, Philipp A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302y-5cb01dbce5926ec904b3510c8e3f3c27b408b123840d6a74c4a22ba2413e9e3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Cardiology</topic><topic>Cicatrix - diagnostic imaging</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardium - pathology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Positron-Emission Tomography</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuchs, Tobias A.</creatorcontrib><creatorcontrib>Ghadri, Jelena R.</creatorcontrib><creatorcontrib>Stehli, Julia</creatorcontrib><creatorcontrib>Gebhard, Catherine</creatorcontrib><creatorcontrib>Kazakauskaite, Egle</creatorcontrib><creatorcontrib>Klaeser, Bernd</creatorcontrib><creatorcontrib>Gaemperli, Oliver</creatorcontrib><creatorcontrib>Fiechter, Michael</creatorcontrib><creatorcontrib>Kaufmann, Philipp A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuchs, Tobias A.</au><au>Ghadri, Jelena R.</au><au>Stehli, Julia</au><au>Gebhard, Catherine</au><au>Kazakauskaite, Egle</au><au>Klaeser, Bernd</au><au>Gaemperli, Oliver</au><au>Fiechter, Michael</au><au>Kaufmann, Philipp A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2012-12</date><risdate>2012</risdate><volume>39</volume><issue>12</issue><spage>1920</spage><epage>1926</epage><pages>1920-1926</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
Methods
Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to
18
F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
Results
Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
Conclusion
Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22926710</pmid><doi>10.1007/s00259-012-2212-y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1619-7070 |
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| issn | 1619-7070 1619-7089 |
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| subjects | Aged Cardiology Cicatrix - diagnostic imaging Coronary Artery Disease - diagnostic imaging Female Fluorodeoxyglucose F18 Heart - diagnostic imaging Humans Imaging Male Medicine Medicine & Public Health Middle Aged Myocardium - pathology Nuclear Medicine Oncology Original Article Orthopedics Positron-Emission Tomography Radiology Radiopharmaceuticals Tomography, Emission-Computed, Single-Photon |
| title | Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET |
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