From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD

Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a s...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2012-10, Vol.27 Suppl 3 (suppl 3), p.iii43-iii50
Hauptverfasser: Prunotto, Marco, Budd, David C, Meier, Matthias, Formentini, Ivan, Hartmann, Guido, Pomposiello, Silvia, Moll, Solange
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container_end_page iii50
container_issue suppl 3
container_start_page iii43
container_title Nephrology, dialysis, transplantation
container_volume 27 Suppl 3
creator Prunotto, Marco
Budd, David C
Meier, Matthias
Formentini, Ivan
Hartmann, Guido
Pomposiello, Silvia
Moll, Solange
description Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.
doi_str_mv 10.1093/ndt/gfs283
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subjects Acute Kidney Injury - physiopathology
Disease Progression
Epithelial-Mesenchymal Transition
Humans
Kidney Failure, Chronic - physiopathology
title From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD
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