From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD
Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a s...
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Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2012-10, Vol.27 Suppl 3 (suppl 3), p.iii43-iii50 |
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container_issue | suppl 3 |
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container_title | Nephrology, dialysis, transplantation |
container_volume | 27 Suppl 3 |
creator | Prunotto, Marco Budd, David C Meier, Matthias Formentini, Ivan Hartmann, Guido Pomposiello, Silvia Moll, Solange |
description | Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD. |
doi_str_mv | 10.1093/ndt/gfs283 |
format | Article |
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The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. 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The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.</description><subject>Acute Kidney Injury - physiopathology</subject><subject>Disease Progression</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - physiopathology</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWw4QOQlwgp1I-8zA6Vp6jEBtbRxHEaFycOtrOIxMcTaGEzo9Ec3RkdhM4puaZE8GVXheWm9iznB2hO45REjOfJIZpPSxqRhIgZOvF-SwgRLMuO0YyxLE8o5XP09eBsi0EOQWHdbQc34mCxbJzttMSV9gq8usE9hMb2zei1NXajJRjcjL0NjfLaY1tj6LDq9TQbDWbZKq862YztxElnvQ9gPjCYoBwEbbvpFF693J2ioxqMV2f7vkDvD_dvq6do_fr4vLpdR5IzHqK4THNRMZESJcoUkrKuOJVQckEzgKqmcV6rOImlkFNhLBakhKxmIqEVSyXjC3S5y-2d_RyUD0WrvVTGQKfs4AtKE0p4HAsxoVc79Pdtp-qid7oFNxaUFD-2i8l2sbM9wRf73KFsVfWP_unl31pzfpc</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Prunotto, Marco</creator><creator>Budd, David C</creator><creator>Meier, Matthias</creator><creator>Formentini, Ivan</creator><creator>Hartmann, Guido</creator><creator>Pomposiello, Silvia</creator><creator>Moll, Solange</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD</title><author>Prunotto, Marco ; Budd, David C ; Meier, Matthias ; Formentini, Ivan ; Hartmann, Guido ; Pomposiello, Silvia ; Moll, Solange</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-4b689d2960e9b6a5bfd31cab3917aadf148fe454c9c54c22490ba7f2951d26c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Kidney Injury - physiopathology</topic><topic>Disease Progression</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prunotto, Marco</creatorcontrib><creatorcontrib>Budd, David C</creatorcontrib><creatorcontrib>Meier, Matthias</creatorcontrib><creatorcontrib>Formentini, Ivan</creatorcontrib><creatorcontrib>Hartmann, Guido</creatorcontrib><creatorcontrib>Pomposiello, Silvia</creatorcontrib><creatorcontrib>Moll, Solange</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prunotto, Marco</au><au>Budd, David C</au><au>Meier, Matthias</au><au>Formentini, Ivan</au><au>Hartmann, Guido</au><au>Pomposiello, Silvia</au><au>Moll, Solange</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2012-10</date><risdate>2012</risdate><volume>27 Suppl 3</volume><issue>suppl 3</issue><spage>iii43</spage><epage>iii50</epage><pages>iii43-iii50</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. 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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
subjects | Acute Kidney Injury - physiopathology Disease Progression Epithelial-Mesenchymal Transition Humans Kidney Failure, Chronic - physiopathology |
title | From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD |
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