A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer

Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test...

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Veröffentlicht in:Cancer letters 2013-01, Vol.328 (1), p.160-167
Hauptverfasser: Shan, Qiang, Lou, Xiaomin, Xiao, Ting, Zhang, Ju, Sun, Huiying, Gao, Yanning, Cheng, Shujun, Wu, Lin, Xu, Ningzhi, Liu, Siqi
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container_end_page 167
container_issue 1
container_start_page 160
container_title Cancer letters
container_volume 328
creator Shan, Qiang
Lou, Xiaomin
Xiao, Ting
Zhang, Ju
Sun, Huiying
Gao, Yanning
Cheng, Shujun
Wu, Lin
Xu, Ningzhi
Liu, Siqi
description Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test set samples, we identified four CTAs are indicator of NSCLC.
doi_str_mv 10.1016/j.canlet.2012.08.019
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subjects Aged
Antigens
Antigens, Neoplasm - immunology
autoantibodies
Autoantibodies - analysis
Biomarker
Biomarkers
Biomarkers, Tumor - analysis
breast neoplasms
Cancer/testis antigen (CTA)
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - immunology
Confidence intervals
Early Detection of Cancer - methods
Female
Hematology, Oncology and Palliative Medicine
Humans
Lung cancer
lung neoplasms
Lung Neoplasms - diagnosis
Lung Neoplasms - immunology
Male
Microarray Analysis - methods
microarray technology
Middle Aged
Non-small cell lung cancer (NSCLC)
Peptides
Protein microarray
Proteins
Sensitivity and Specificity
Studies
testes
title A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer
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