A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer
Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test...
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Veröffentlicht in: | Cancer letters 2013-01, Vol.328 (1), p.160-167 |
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container_title | Cancer letters |
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creator | Shan, Qiang Lou, Xiaomin Xiao, Ting Zhang, Ju Sun, Huiying Gao, Yanning Cheng, Shujun Wu, Lin Xu, Ningzhi Liu, Siqi |
description | Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test set samples, we identified four CTAs are indicator of NSCLC. |
doi_str_mv | 10.1016/j.canlet.2012.08.019 |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 1, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-2cd86b0f153966e8c7fcc63039dad08c2d0a09045b1bfc1d8a04587054db8adb3</citedby><cites>FETCH-LOGICAL-c535t-2cd86b0f153966e8c7fcc63039dad08c2d0a09045b1bfc1d8a04587054db8adb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383512005071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22922091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shan, Qiang</creatorcontrib><creatorcontrib>Lou, Xiaomin</creatorcontrib><creatorcontrib>Xiao, Ting</creatorcontrib><creatorcontrib>Zhang, Ju</creatorcontrib><creatorcontrib>Sun, Huiying</creatorcontrib><creatorcontrib>Gao, Yanning</creatorcontrib><creatorcontrib>Cheng, Shujun</creatorcontrib><creatorcontrib>Wu, Lin</creatorcontrib><creatorcontrib>Xu, Ningzhi</creatorcontrib><creatorcontrib>Liu, Siqi</creatorcontrib><title>A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test set samples, we identified four CTAs are indicator of NSCLC.</description><subject>Aged</subject><subject>Antigens</subject><subject>Antigens, Neoplasm - immunology</subject><subject>autoantibodies</subject><subject>Autoantibodies - analysis</subject><subject>Biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>breast neoplasms</subject><subject>Cancer/testis antigen (CTA)</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - immunology</subject><subject>Confidence intervals</subject><subject>Early Detection of Cancer - methods</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>lung neoplasms</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - immunology</subject><subject>Male</subject><subject>Microarray Analysis - methods</subject><subject>microarray technology</subject><subject>Middle Aged</subject><subject>Non-small cell lung cancer (NSCLC)</subject><subject>Peptides</subject><subject>Protein microarray</subject><subject>Proteins</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>testes</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1q3DAUhUVpaSZp36C0gm6ysXMlWba8KYTQPwh0kWYtZEkeNLGtVLID8_a9xtMWsulGFua7h3vOESHvGJQMWH11KK2ZBj-XHBgvQZXA2hdkx1TDi6ZV8JLsQEBVCCXkGTnP-QAAsmrka3LGecs5tGxHumuKMtanq9nnOWRqpjns_UTHYFM0KZkjnSPNNnn8aZY5rkAX3ZF2IY4mPfiUaezpFKcij2YYqPV4DMu0Pym_Ia96M2T_9vS9IPdfPv-8-Vbc_vj6_eb6trBSyLng1qm6g55J0da1V7bpra0FiNYZB8pyBwZaqGTHut4ypwzeVYOWXKeM68QFudx0H1P8taAbPYa8LmMmH5esGZMMRFVxhujHZ-ghLmnC7TSrK4mBgmiQqjYKk8g5-V4_poCWj5qBXjvQB711oNcONCiNHeDY-5P40o3e_R36EzoCHzagN1GbfQpZ39-hgsSChOCsQuLTRnjM6yn4pLMNHsN0IXk7axfD_3Z4LmCHMAVrhgd_9PmfW51xRt-tL2V9KGgcJDRM_AawQLeT</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Shan, Qiang</creator><creator>Lou, Xiaomin</creator><creator>Xiao, Ting</creator><creator>Zhang, Ju</creator><creator>Sun, Huiying</creator><creator>Gao, Yanning</creator><creator>Cheng, Shujun</creator><creator>Wu, Lin</creator><creator>Xu, Ningzhi</creator><creator>Liu, Siqi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer</title><author>Shan, Qiang ; Lou, Xiaomin ; Xiao, Ting ; Zhang, Ju ; Sun, Huiying ; Gao, Yanning ; Cheng, Shujun ; Wu, Lin ; Xu, Ningzhi ; Liu, Siqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-2cd86b0f153966e8c7fcc63039dad08c2d0a09045b1bfc1d8a04587054db8adb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Antigens</topic><topic>Antigens, Neoplasm - immunology</topic><topic>autoantibodies</topic><topic>Autoantibodies - analysis</topic><topic>Biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>breast neoplasms</topic><topic>Cancer/testis antigen (CTA)</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - immunology</topic><topic>Confidence intervals</topic><topic>Early Detection of Cancer - methods</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>lung neoplasms</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - immunology</topic><topic>Male</topic><topic>Microarray Analysis - methods</topic><topic>microarray technology</topic><topic>Middle Aged</topic><topic>Non-small cell lung cancer (NSCLC)</topic><topic>Peptides</topic><topic>Protein microarray</topic><topic>Proteins</topic><topic>Sensitivity and Specificity</topic><topic>Studies</topic><topic>testes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shan, Qiang</creatorcontrib><creatorcontrib>Lou, Xiaomin</creatorcontrib><creatorcontrib>Xiao, Ting</creatorcontrib><creatorcontrib>Zhang, Ju</creatorcontrib><creatorcontrib>Sun, Huiying</creatorcontrib><creatorcontrib>Gao, Yanning</creatorcontrib><creatorcontrib>Cheng, Shujun</creatorcontrib><creatorcontrib>Wu, Lin</creatorcontrib><creatorcontrib>Xu, Ningzhi</creatorcontrib><creatorcontrib>Liu, Siqi</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shan, Qiang</au><au>Lou, Xiaomin</au><au>Xiao, Ting</au><au>Zhang, Ju</au><au>Sun, Huiying</au><au>Gao, Yanning</au><au>Cheng, Shujun</au><au>Wu, Lin</au><au>Xu, Ningzhi</au><au>Liu, Siqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>328</volume><issue>1</issue><spage>160</spage><epage>167</epage><pages>160-167</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test set samples, we identified four CTAs are indicator of NSCLC.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22922091</pmid><doi>10.1016/j.canlet.2012.08.019</doi><tpages>8</tpages></addata></record> |
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subjects | Aged Antigens Antigens, Neoplasm - immunology autoantibodies Autoantibodies - analysis Biomarker Biomarkers Biomarkers, Tumor - analysis breast neoplasms Cancer/testis antigen (CTA) Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - immunology Confidence intervals Early Detection of Cancer - methods Female Hematology, Oncology and Palliative Medicine Humans Lung cancer lung neoplasms Lung Neoplasms - diagnosis Lung Neoplasms - immunology Male Microarray Analysis - methods microarray technology Middle Aged Non-small cell lung cancer (NSCLC) Peptides Protein microarray Proteins Sensitivity and Specificity Studies testes |
title | A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer |
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