A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer

Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test...

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Veröffentlicht in:	Cancer letters 2013-01, Vol.328 (1), p.160-167
Hauptverfasser:	Shan, Qiang, Lou, Xiaomin, Xiao, Ting, Zhang, Ju, Sun, Huiying, Gao, Yanning, Cheng, Shujun, Wu, Lin, Xu, Ningzhi, Liu, Siqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens Antigens, Neoplasm - immunology autoantibodies Autoantibodies - analysis Biomarker Biomarkers Biomarkers, Tumor - analysis breast neoplasms Cancer/testis antigen (CTA) Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - immunology Confidence intervals Early Detection of Cancer - methods Female Hematology, Oncology and Palliative Medicine Humans Lung cancer lung neoplasms Lung Neoplasms - diagnosis Lung Neoplasms - immunology Male Microarray Analysis - methods microarray technology Middle Aged Non-small cell lung cancer (NSCLC) Peptides Protein microarray Proteins Sensitivity and Specificity Studies testes
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Beschreibung
Zusammenfassung:	Highlights ► It’s the first survey of autoantibodies in the serum of NSCLC using a comprehensive number of CTA. ► Our results greatly enrich our knowledge of the auto-immunity of CTAs in cancers and will definitely benefit future research in this area. ► By screening 377 sera from training and test set samples, we identified four CTAs are indicator of NSCLC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.08.019