Free-radical oxidation of plasma fibrin-stabilizing factor

Fibrin stabilizing factor (FXIII) belongs to the family of transglutaminases (endo glutamine: lysine transferase, EC. 2.3.2.13) and is one of the key proteins of the blood coagulation system. The purpose of this study was to investigate the effect of free radical oxidation on the structural and func...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2012-09, Vol.446 (1), p.213-216
Hauptverfasser:	Rosenfeld, M. A., Shegolihin, A. N., Bychkova, A. V., Leonova, V. B., Kostanova, E. A., Biryukova, M. I., Razumovskii, S. D., Konstantinova, M. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Binding Sites Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Catalysis Factor XIII - chemistry Factor XIII - ultrastructure Factor XIIIa - chemistry Factor XIIIa - ultrastructure Free radicals Free Radicals - chemistry Life Sciences Oxidation Oxidation-Reduction Protein Binding Protein Conformation Proteins
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Zusammenfassung:	Fibrin stabilizing factor (FXIII) belongs to the family of transglutaminases (endo glutamine: lysine transferase, EC. 2.3.2.13) and is one of the key proteins of the blood coagulation system. The purpose of this study was to investigate the effect of free radical oxidation on the structural and functional properties of fibrin stabilizing factor at dif ferent stages of its activation and to obtain data on the antioxidant role of FXIII 2.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672912050018