Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis in Vitro

New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C12(EO)21) and O,O′-ditetradecanoyl-N-(α-trimethylammonioacetyl) diethanolamine chloride (2C14ECl) were produced. Cationic HLs were smaller and more stable th...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2012/11/01, Vol.35(11), pp.2097-2101
Hauptverfasser:	Hino, Motoki, Ichihara, Hideaki, Matsumoto, Yoko, Ueoka, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage apoptosis Apoptosis - drug effects Carcinoma Cell Proliferation - drug effects colon carcinoma Colonic Neoplasms Dimyristoylphosphatidylcholine - administration & dosage Dimyristoylphosphatidylcholine - chemistry Ethanolamines - administration & dosage Ethanolamines - chemistry HCT116 Cells Humans hybrid liposome Liposomes Membrane Potential, Mitochondrial - drug effects Myristates - administration & dosage Myristates - chemistry Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry
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Zusammenfassung:	New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C12(EO)21) and O,O′-ditetradecanoyl-N-(α-trimethylammonioacetyl) diethanolamine chloride (2C14ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human colon cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.b12-00633