Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis

Highlights ► ALAC has anticonvulsant properties. ► ALAC might prevent seizure development. ► ALAC displays antiepileptogenic properties. ► ALAC might act also through kynurenic acid.

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.282-288
Hauptverfasser:	Russo, E, Scicchitano, F, Citraro, R, Aiello, R, Camastra, C, Mainardi, P, Chimirri, S, Perucca, E, Donato, G, De Sarro, G
Format:	Artikel
Sprache:	eng
Schlagworte:	absence epilepsy Animals antiepileptogenesis Biological and medical sciences Convulsants Epilepsy - chemically induced Epilepsy - pathology Epilepsy - prevention & control Epilepsy, Absence - chemically induced Epilepsy, Absence - prevention & control Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - pathology Kynurenic Acid Lactalbumin - chemistry Lactalbumin - pharmacology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Milk Proteins - chemistry Milk Proteins - pharmacology N-Methylaspartate Nervous system (semeiology, syndromes) Neurology Pentylenetetrazole Pilocarpine Rats spike-wave discharges Tryptophan - chemistry Tryptophan - pharmacology WAG/Rij rats Whey Proteins
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Zusammenfassung:	Highlights ► ALAC has anticonvulsant properties. ► ALAC might prevent seizure development. ► ALAC displays antiepileptogenic properties. ► ALAC might act also through kynurenic acid.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.021