Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population

A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as pote...

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Veröffentlicht in:	The Journal of infectious diseases 2012-12, Vol.206 (11), p.1763-1767
Hauptverfasser:	Grant, Audrey V., Alter, Andrea, Huong, Nguyen Thu, Orlova, Marianna, Van Thuc, Nguyen, Ba, Nguyen Ngoc, Thai, Vu Hong, Abel, Laurent, Schurr, Erwin, Alcais, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Asian Continental Ancestry Group - genetics BACTERIA Bacterial diseases Biological and medical sciences Crohn disease Crohn Disease - genetics Family Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetic loci Genetic Predisposition to Disease Genotype Human bacterial diseases Human genetics Humans Infectious diseases Leprosy Leprosy - epidemiology Leprosy - genetics Medical sciences Microbiology Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism P values Polymorphism, Single Nucleotide Population genetics Research universities Signal Transduction Sinology Tropical bacterial diseases Universities Vietnam - epidemiology
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Zusammenfassung:	A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and N0D2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jis588