Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus

Highlights ► Bryostatin-1 enhances the induction of hippocampal LTP. ► Facilitative effects of bryostatin-1 result from activation of PKCα or PKCε. ► Bryostatin-1 elevates intracellular calcium via activation of PKCα or PKCε. ► Facilitative effects of bryostatin-1 require activation of NMDA receptor...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.348-355
Hauptverfasser:	Kim, H, Han, S.H, Quan, H.Y, Jung, Y.-J, An, J, Kang, P, Park, J.-B, Yoon, B.-J, Seol, G.H, Min, S.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences bryostatin-1 Bryostatins - pharmacology Calcium - metabolism Cells, Cultured Central nervous system Data Interpretation, Statistical Dose-Response Relationship, Drug Electric Stimulation Electrophysiological Phenomena Electrophysiology Enzyme Activation - drug effects Enzyme Activators - pharmacology Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - drug effects Hippocampus - enzymology In Vitro Techniques Isoenzymes - chemistry Isoenzymes - metabolism long-term potentiation (LTP) Long-Term Potentiation - drug effects Male Mice Mice, Inbred C57BL Neurology protein kinase C (PKC) Protein Kinase C-alpha - metabolism Protein Kinase C-epsilon - metabolism synaptic plasticity Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Bryostatin-1 enhances the induction of hippocampal LTP. ► Facilitative effects of bryostatin-1 result from activation of PKCα or PKCε. ► Bryostatin-1 elevates intracellular calcium via activation of PKCα or PKCε. ► Facilitative effects of bryostatin-1 require activation of NMDA receptors.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.08.055