Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure...

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Veröffentlicht in:Hypertension research 2012-11, Vol.35 (11), p.1102-1110
Hauptverfasser: Asayama, Kei, Ohkubo, Takayoshi, Metoki, Hirohito, Obara, Taku, Inoue, Ryusuke, Kikuya, Masahiro, Thijs, Lutgarde, Staessen, Jan A, Imai, Yutaka
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Angiotensin II Type 1 Receptor Blockers - pharmacology
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory
Calcium Channel Blockers - pharmacology
Calcium Channel Blockers - therapeutic use
Cardiovascular Diseases - epidemiology
Female
Follow-Up Studies
Humans
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - physiopathology
Male
Middle Aged
Prospective Studies
Risk Factors
Treatment Outcome
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Zusammenfassung:Hypertension guidelines recommend blood pressure self-measurement at home (HBP), but no previous trial has assessed cardiovascular outcomes in hypertensive patients treated according to HBP. The multicenter Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP; 2001-2010) trial involved 3518 patients (50% women; mean age 59.6 years) with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg. In a 2 × 3 design, patients were randomized to usual control (125-134/80-84 mm Hg (UC)) vs. tight control (
ISSN:0916-9636
1348-4214
DOI:10.1038/hr.2012.125