Very-Long-Distance Correlations in Proteins Revealed by Solid-State NMR Spectroscopy

I still see you: A new pulse sequence, SHA+, little sensitive to dipolar truncation, allows direct or relayed polarization transfer between 13C atoms, distant by 3.5–9.6 Å, in amyloid fibrils (see picture). SHA+ can also be used in a broadband way with the weak rf‐condition of ν1/νR≈0.2–0.3 which pe...

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Veröffentlicht in:	Chemphyschem 2012-11, Vol.13 (16), p.3585-3588
Hauptverfasser:	Hu, Bingwen, Trébosc, Julien, Lafon, Oliver, Chen, Qun, Masuda, Yuichi, Takegoshi, K., Amoureux, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-peptides Amyloid beta-Peptides - chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects, investigation methods Humans magic-angle spinning Models, Molecular NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular - methods Peptide Fragments - chemistry polarization transfer Protein Conformation protein structures Proteins Temperature
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	I still see you: A new pulse sequence, SHA+, little sensitive to dipolar truncation, allows direct or relayed polarization transfer between 13C atoms, distant by 3.5–9.6 Å, in amyloid fibrils (see picture). SHA+ can also be used in a broadband way with the weak rf‐condition of ν1/νR≈0.2–0.3 which permits the investigation of temperature‐sensitive biological systems.
ISSN:	1439-4235 1439-7641
DOI:	10.1002/cphc.201200548