Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis
Highlights ► Progesterone attenuates signs of experimental autoimmune encephalomyelitis (EAE). ► Progesterone decreases proinflammatory mediators in the spinal cord of EAE mice. ► Progesterone increases transcription of myelin proteins in EAE mice. ► Progesterone increases myelin transcription facto...
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| Veröffentlicht in: | Neuroscience 2012-12, Vol.226, p.40-50 |
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| creator | Garay, L.I González Deniselle, M.C Brocca, M.E Lima, A Roig, P De Nicola, A.F |
| description | Highlights ► Progesterone attenuates signs of experimental autoimmune encephalomyelitis (EAE). ► Progesterone decreases proinflammatory mediators in the spinal cord of EAE mice. ► Progesterone increases transcription of myelin proteins in EAE mice. ► Progesterone increases myelin transcription factors in EAE mice. ► Progesterone exerts direct effects on the spinal cord of EAE mice. |
| doi_str_mv | 10.1016/j.neuroscience.2012.09.032 |
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Meninges. Spinal cord</topic><topic>Down-Regulation - drug effects</topic><topic>Encephalomyelitis, Autoimmune, Experimental - drug therapy</topic><topic>Encephalomyelitis, Autoimmune, Experimental - metabolism</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>experimental autoimmune encephalomyelitis</topic><topic>Female</topic><topic>Immunohistochemistry</topic><topic>Inflammation Mediators - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microfilament Proteins - biosynthesis</topic><topic>Microfilament Proteins - genetics</topic><topic>Microglia - metabolism</topic><topic>Microscopy, Confocal</topic><topic>myelin proteins</topic><topic>Myelin Proteins - biosynthesis</topic><topic>Myelin Sheath - drug effects</topic><topic>Myelin Sheath - pathology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>neuroprotection</topic><topic>Oligodendroglia - drug effects</topic><topic>Oligodendroglia - metabolism</topic><topic>progesterone</topic><topic>Progesterone - pharmacology</topic><topic>proinflammatory mediators</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - metabolism</topic><topic>transcription factors</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garay, L.I</creatorcontrib><creatorcontrib>González Deniselle, M.C</creatorcontrib><creatorcontrib>Brocca, M.E</creatorcontrib><creatorcontrib>Lima, A</creatorcontrib><creatorcontrib>Roig, P</creatorcontrib><creatorcontrib>De Nicola, A.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garay, L.I</au><au>González Deniselle, M.C</au><au>Brocca, M.E</au><au>Lima, A</au><au>Roig, P</au><au>De Nicola, A.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2012-12-13</date><risdate>2012</risdate><volume>226</volume><spage>40</spage><epage>50</epage><pages>40-50</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights ► Progesterone attenuates signs of experimental autoimmune encephalomyelitis (EAE). ► Progesterone decreases proinflammatory mediators in the spinal cord of EAE mice. ► Progesterone increases transcription of myelin proteins in EAE mice. ► Progesterone increases myelin transcription factors in EAE mice. ► Progesterone exerts direct effects on the spinal cord of EAE mice.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>23000619</pmid><doi>10.1016/j.neuroscience.2012.09.032</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Cerebrospinal fluid. Meninges. Spinal cord Down-Regulation - drug effects Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology experimental autoimmune encephalomyelitis Female Immunohistochemistry Inflammation Mediators - metabolism Medical sciences Mice Mice, Inbred C57BL Microfilament Proteins - biosynthesis Microfilament Proteins - genetics Microglia - metabolism Microscopy, Confocal myelin proteins Myelin Proteins - biosynthesis Myelin Sheath - drug effects Myelin Sheath - pathology Nervous system (semeiology, syndromes) Neurology neuroprotection Oligodendroglia - drug effects Oligodendroglia - metabolism progesterone Progesterone - pharmacology proinflammatory mediators Real-Time Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Spinal Cord - drug effects Spinal Cord - metabolism transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics |
| title | Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis |
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