Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis

Highlights ► Progesterone attenuates signs of experimental autoimmune encephalomyelitis (EAE). ► Progesterone decreases proinflammatory mediators in the spinal cord of EAE mice. ► Progesterone increases transcription of myelin proteins in EAE mice. ► Progesterone increases myelin transcription facto...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.40-50
Hauptverfasser:	Garay, L.I, González Deniselle, M.C, Brocca, M.E, Lima, A, Roig, P, De Nicola, A.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Cerebrospinal fluid. Meninges. Spinal cord Down-Regulation - drug effects Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology experimental autoimmune encephalomyelitis Female Immunohistochemistry Inflammation Mediators - metabolism Medical sciences Mice Mice, Inbred C57BL Microfilament Proteins - biosynthesis Microfilament Proteins - genetics Microglia - metabolism Microscopy, Confocal myelin proteins Myelin Proteins - biosynthesis Myelin Sheath - drug effects Myelin Sheath - pathology Nervous system (semeiology, syndromes) Neurology neuroprotection Oligodendroglia - drug effects Oligodendroglia - metabolism progesterone Progesterone - pharmacology proinflammatory mediators Real-Time Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Spinal Cord - drug effects Spinal Cord - metabolism transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics
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Zusammenfassung:	Highlights ► Progesterone attenuates signs of experimental autoimmune encephalomyelitis (EAE). ► Progesterone decreases proinflammatory mediators in the spinal cord of EAE mice. ► Progesterone increases transcription of myelin proteins in EAE mice. ► Progesterone increases myelin transcription factors in EAE mice. ► Progesterone exerts direct effects on the spinal cord of EAE mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.032