Gastric acid secretion induced by paraventricular nucleus microinjection of orexin A is mediated through activation of neuropeptide Yergic system

Highlights ► ICV microinjections of Y1 and Y5 antagonists decreased gastric acid secretion. ► Stimulatory effect of PVN orexin on acid secretion is inhibited by Y1 and Y5 receptors antagonists. ► The stimulatory effect of PVN orexin on acid secretion may be induced by Y1 and Y5 receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.81-88
Hauptverfasser:	Kermani, M, Eliassi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Gastric Acid - secretion Gastric Juice - secretion hypothalamic paraventricular nucleus Intracellular Signaling Peptides and Proteins - administration & dosage Intracellular Signaling Peptides and Proteins - pharmacology Male Microinjections Naphthalenes - administration & dosage Naphthalenes - pharmacology Neurology Neuropeptide Y - antagonists & inhibitors Neuropeptide Y - physiology Neuropeptides - administration & dosage Neuropeptides - pharmacology NPY Y1 and Y5 receptors Orexins Paraventricular Hypothalamic Nucleus - drug effects Peptides, Cyclic - administration & dosage Peptides, Cyclic - pharmacology pylorus ligation Pyrimidines - administration & dosage Pyrimidines - pharmacology Rats Rats, Wistar Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - drug effects Receptors, Neuropeptide - antagonists & inhibitors Receptors, Neuropeptide - drug effects Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - drug effects Stomach Vertebrates: digestive system
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Beschreibung
Zusammenfassung:	Highlights ► ICV microinjections of Y1 and Y5 antagonists decreased gastric acid secretion. ► Stimulatory effect of PVN orexin on acid secretion is inhibited by Y1 and Y5 receptors antagonists. ► The stimulatory effect of PVN orexin on acid secretion may be induced by Y1 and Y5 receptors.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.08.052