Unusual Pyrrolyl 4-Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium sp. ghq208

One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by sp...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/11/01, Vol.60(11), pp.1458-1460
Hauptverfasser:	Gao, Huquan, Zhang, Lianqing, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Quinolones - chemistry 4-Quinolones - isolation & purification 4-Quinolones - pharmacology alkaloid Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Survival - drug effects Hep G2 Cells Humans Inhibitory Concentration 50 Liver Neoplasms - drug therapy marine-derived fungus Penicillium Penicillium - chemistry penicinoline Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology
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Zusammenfassung:	One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC50 values of 11.3 and 13.2 µM, respectively.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c12-00487